Pathological Research Progress of Obsessive-compulsive Disorder in Children and Adolescents

Abstract

Obsessive-compulsive disorder is a typical mental disorder, which has a lasting impact on children and adolescents’ life and learning. Multidisciplinary studies have explored the pathological mechanism of obsessive-compulsive disorder from different angles. Imaging studies have found that the structural and functional connections of multiple brain regions in children and adolescents with obsessive-compulsive disorder are abnormal, and cerebral blood flow and metabolic level of brain tissue are abnormal. Biological studies show that there are abnormalities in neurotransmitter metabolism, genes and cytokines in children and adolescents with obsessive-compulsive disorder.  Cognitive behavior research holds that children and adolescents with obsessive-compulsive disorder have different cognitive functions such as memory and attention from normal children. Although the above research results are controversial, they have important reference value for in-depth study of the pathology of obsessive-compulsive disorder and intervention of children and adolescents with obsessive-compulsive disorder.